Cascade polymer complexes, process for producing the same and pharmaceuticals containing the same

US6057419A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Heribert Schmitt-Willich · Berlin, DE
• Johannes Platzek · Berlin, DE
• Bernd Raduchel · Berlin, DE
• Hanns-Joachim Weinmann · Berlin, DE
• Wolfgang Ebert · Krefeld, DE
• Bernd Misselwitz · Berlin, DE
• Andreas Muhler · Oderberg, DE
• Thomas Frenzel · Berlin, DE

Key dates

• Filing date: Jun 4, 1998
• Grant date: May 2, 2000
• Expiry date: Jun 4, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/124
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Cascade polymer complexes that contain a) complexing ligands of general formula (I), in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different, and that 16.ltoreq.a.multidot.x.multidot.y.multidot.z.multidot.w.ltoreq.64 holds true for the product of the multiplicities and that at least one of cascade reproduction units X, Y, Z, W stands for a 1,4,7,10-tetraazacyclododecane or 1,4,8,11-teraazacyclotetradecane reproduction unit, b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides as well as d) optionally acylated terminal amino groups are valuable compounds for diagnosis and therapy.