Antisense nucleic acid compounds inhibiting vascular endothelial growth factor
US6057437A · kind A · utility
44Cited by
2References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 21, 1998 |
| Grant date | May 2, 2000 |
| Priority date | — |
| Expiry date | Jul 21, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/315
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides an antisense nucleic acid compound inhibiting expression of vascular endothelial growth factor as well as therapeutic and diagnostic agents comprising the same as an active ingredient. A compound which nucleotide sequence is substantially complementary to a nucleotide sequence located upstream of a translation region in a gene coding for vascular endothelial growth factor and which inhibits 50% or more of the expression of vascular endothelial growth factor in cells is used as the antisense nucleic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.