Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US6057453A · kind A · utility
3Cited by
41References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 30, 1999 |
| Grant date | May 2, 2000 |
| Priority date | — |
| Expiry date | Sep 30, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F15/0093
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a method for making radiosensitizing diamines. This method comprises converting a compound having formula (5): ##STR1## to a compound having formula (6): ##STR2## using dimethyl sulfoxide activated by oxalyl chloride, and the treating the compound having formula (6) with a diamine reagent in the presence of an organic acid and a reducing agent. The radiosensitizing diamines formed by this method have formula (1): ##STR3##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.