Method for producing transdermal patches (TTS)

US6059913A · kind A · utility

Assignee

• LTS Lohmann Therapie-Systeme AG · DE

Inventors

• Bodo Asmussen · Bendorf, DE
• Thomas Hille · Neuwied, DE
• Klaus Schumann · Weil am Rhein, DE
• Peter Steinborn · Neuwied, DE

Key dates

• Filing date: Oct 30, 1998
• Grant date: May 9, 2000
• Expiry date: Oct 30, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T156/1967
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for the continuous production of transdermal therapeutic patches, wherein a laminate of an auxiliary layer (3) siliconized at least on one side, an active substance-containing, pressure-sensitive adhesive layer (4), and a supporting layer (9) is prepared as a strip-shaped web (1) first, and the active substance-containing sections (4') obtained by punching said layers (3) and (4) across the web direction are intermittently transferred onto a second web (2), the punching procedure taking place in the rest phase between the cycles and the transfer procedure onto the second web (2) being carried out preferably at equal distances by means of a transfer device (11, 12), is characterized by the fact that the supporting layer (9) is stripped from the active substance-containing sections (4') during the transfer first, and that then the sections (3') of the auxiliary layer are removed with the aid of a process layer (5) which has been rendered pressure-sensitive adhesive.