Thiadiazole compounds useful as inhibitors of H.sup.+ /K.sup.+ atpase
US6060472A · kind A · utility
3Cited by
1References
21Claims
0Family size
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Key dates
| Filing date | Apr 6, 1998 |
| Grant date | May 9, 2000 |
| Priority date | — |
| Expiry date | Apr 6, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 3,5-disubstituted 1,2,4-thiadiazole compounds are provided, which are effective in treating peptic ulcers by the inhibition of H.sup.+ /K.sup.+ -ATPase. The compounds of the present invention are 3,5-disubstituted 1,2,4-thiadiazole corresponding to the general formula (I): ##STR1## where R.sup.1 is a group with cell penetration properties for the inhibition of the enzyme in-vitro and in-vivo, and Y is a substituent that tunes the reactivity of the inhibitor towards the cysteine residue of H.sup.+ /K.sup.+ -ATPase. The Y group may also serve in recognition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.