Antineurodegenerative ergoline derivatives

US6060483A · kind A · utility

Assignee

• Pharmacia & Upjohn S.p.A. · IT

Inventors

• Sergio Mantegani · Milano, IT
• Enzo Brambilla · Mariano Comense, IT
• Nicola Carfagna · Milano, IT
• Mario Varasi · Milano, IT

Key dates

• Filing date: Dec 28, 1998
• Grant date: May 9, 2000
• Expiry date: Dec 28, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D457/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides the new use in the treatment of neurodegenerative diseases with ergoline derivatives of formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom or a linear or branched C.sub.1 -C.sub.5 alkyl or C.sub.2 -C.sub.5 alkenyl group optionally substituted with a C.sub.3 -C.sub.7 cycloalkyl, a hydroxy group or a R.sub.3 -substituted phenyl group wherein R.sub.3 is a hydroxy or a hydroxymethyl group; R.sub.2 represents a hydrogen atom or a linear or branched C.sub.1 -C.sub.5 alkyl or a C.sub.2 -C.sub.5 alkenyl group optionally substituted with a hydroxy group, or a R.sub.3 -substituted phenyl group wherein R.sub.3 is as above defined, or with a C.sub.1 -C.sub.5 alkoxy group; the symbols--at positions 2,3 and 8, 9 independently denote a single or double chemical bond and Z represents a group (CH.sub.2).sub.n OH, wherein n is 0 or an integer from 1 to 3, or a group C(R.sub.4).sub.2 OH wherein R.sub.4 is a C.sub.1 -C.sub.5 alkyl or a phenyl group, or a pharmaceutically acceptable salt thereof. Some compounds of formula (I) are novel. Processes for their preparation and pharmaceutical compositions containing them are also described.