.beta.-polypeptide foldamers of well-defined secondary structure

US6060585A · kind A · utility

Assignee

• Wisconsin Alumni Research Foundation · US

Inventors

• Samuel H. Gellman · Madison, US
• Daniel H. Appella · Rockville, US
• Laurie A. Christianson · Wilmington, US
• Daniel A. Klein · Madison, US
• Susanne Krauthäuser · Overath, DE
• Yong-Jun Chung · Madison, US
• Xifang Wang · Acton, US

Key dates

• Filing date: Mar 4, 1998
• Grant date: May 9, 2000
• Expiry date: Mar 4, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are .beta.-peptides containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the .alpha. and .beta. carbons of the peptide backbone. The .beta.-peptides adopt stable helical and sheet structures in both the solid state and in solution. Method of generating combinatorial libraries of peptides containing .beta.-peptide residues and the libraries formed thereby are disclosed.