Process for the preparation of fine particle pharmaceutical formulations

US6063313A · kind A · utility

Assignee

• Abbott Laboratories · US

Inventors

• Jacqueline Briskin · Buffalo Grove, US
• Pramod Gupta · Bedburg, DE
• Claud Loyd · Beach Park, US
• Robert Köhler · Leipzig, DE
• Susan J. Semla · Evanston, US

Key dates

• Filing date: May 30, 1996
• Grant date: May 16, 2000
• Expiry date: May 30, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/1694
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for preparing fine particle pharmaceutical formulations having improved throughput and producing greater uniformity of particle size. The process relates to adding to the dry components of the formulation prior to the steps of wetting, extrusion and spheronization, an extrusion aid material selected from pharmaceutically acceptable oils and waxes having a drop point between about 15.degree. C. and 115.degree. C.