Preparation of factor IX
US6063909A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 3, 1993 |
| Grant date | May 16, 2000 |
| Priority date | — |
| Expiry date | Aug 3, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/21022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel method of protecting blood coagulation factor IX from proteases during purification or storage is disclosed. High concentrations of one or more water soluble organic or inorganic salts are used to stabilize factor IX, contained within blood plasma-derived solutions, or contained within solutions derived from other sources, against conversion to clinically unacceptable peptide structures such as factor IX.sub.a, and/or degraded factor IX peptides. The technique is useful in stabilizing intermediate purity factor IX preparations during purification, and in maintaining the integrity of purified factor IX during long term storage. Stable high specific activity factor IX preparations are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.