Use of antibodies to sialidase as anti-infectious agents and anti-inflammatory agents

US6066323A · kind A · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Alan Cross · Chevy Chase Section Five, US
• Nicholas Stamatos · Washington, US
• Peter Gomatos · Jacksonville, US

Key dates

• Filing date: Oct 23, 1996
• Grant date: May 23, 2000
• Expiry date: Oct 23, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Sialic acids have the ability to prevent hyposialylation of cells as comptive inhibitors of endogenous sialidase. It is now also possible to develop antibodies to mammalian sialidase that significantly reduce influx of neutrophils into inflammatory sites.