Method for producing a rapidly dissolving dosage form

US6066337A · kind A · utility

Assignee

• The Board of Regents of the University of Oklahoma and Janssen · US

Inventors

• Loyd V. Allen, Jr. · Edmond, US
• Bingnan Wang · Oklahoma City, US
• John Desmond Davies · Grosse Pointe Farms, US

Key dates

• Filing date: Jul 6, 1998
• Grant date: May 23, 2000
• Expiry date: Jul 6, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2063
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A particulate support matrix, and a dosage form made therefrom, and processes for making such support matrices and dosage forms, which disintegrate or dissolve in a matter of just a few seconds once placed into an aqueous environment. First, a porous particulate powder matrix which will serve as the dosage form matrix is produced. In a second step, the pharmaceutical, for example an antihistamine, decongestant, or antibiotic is combined with the powder. Other additives may also be added to the mixture. In a third step the mixture is formed into a dosage form. Finally, in a fourth step, a coating may be formed upon the outer surface of the dosage form to enhance the intactness and durability of the dosage form.