Process for the diagnostic assessment and monitoring, as well as medicaments for the therapy of states of shock in humans

US6066465A · kind A · utility

Assignee

• Paz Arzneimittelentwicklungsgesellschaft mbH · DE

Inventors

• Holger Bang · Erlangen, DE
• Kay Brune · Marloffstein, DE
• Albrecht Wendel · Bingen, DE
• Gesa Tiegs · Konstanz, DE

Key dates

• Filing date: Jun 3, 1997
• Grant date: May 23, 2000
• Expiry date: Jun 3, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/106664
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method is provided for detecting shock by measuring the concentration of cyclophilins in a patient's blood and comparing the measured concentration against a control. The severity of shock is then evaluated, an increase in cyclophilin concentrations over control levels being associated with severity. Measuring methods include enzymological techniques, such as rotomase activity assay; immunological procedures, such as radioimmunoassay and ELISA; peptide chemical processes, such as affinity chromatography; and radiochemical approaches, such as contacting the sample with radioactive cyclosporin.