4-phenyl-3-substituted 1,4-dihydropyridine esters

US6066655A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Heinrich Meier · Wuppertal, DE
• Wolfgang Hartwig · Wuppertal, DE
• Bodo Junge · Wuppertal, DE
• Rudolf Schohe-Loop · Wuppertal, DE
• Zhan Gao · Beijing, CN
• Bernard Schmidt · Lindlar, DE
• Maarten de Jonge · Overath, DE
• Teunis Schuurman · Overath, DE

Key dates

• Filing date: Dec 10, 1997
• Grant date: May 23, 2000
• Expiry date: Dec 10, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

4-Phenyl-3-substituted 1,4-dihydropyridine esters are prepared by reaction of benzaldehydes with ketoesters and enamines, if appropriate with isolation of the ylidene intermediate products, or by esterification of corresponding dihydropyridinecarboxylic acids with alcohols. The new 4-phenyl-3-substituted 1,4-dihydropyridine esters can be employed as active compounds in medicaments for the treatment of the central nervous system, in particular as cerebral therapeutics.