Skin lightening compositions

US6068834A · kind A · utility

Assignee

• The Procter & Gamble Company · US

Inventors

• Kalla Lynn Kvalnes · Cambridge, US
• Mitchell A. deLong · Chapel Hill, US
• Barton James Bradbury · Sharonville, US
• Curtis Bobby Motley · Sharonville, US
• John David Carter · Bolingbrook, US

Key dates

• Filing date: Feb 24, 1995
• Grant date: May 30, 2000
• Expiry date: Feb 24, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/582
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to compositions, compounds and methods for lightening skin, using active compounds having the structure: ##STR1## wherein: (i) each X is, independently, selected from the group consisting of halo, alkyl, substituted alkyl, aryl, OR, OCOR, COR, CONRR COOR, CN, SR, SOR, SO.sub.2 R, SO.sub.3 R and NRR, wherein X is other than hydroxy, amino and thio, if this X is attached ortho to the phenol hydroxy; PA0 (ii) m is an integer from 0 to 4; PA0 (iii) each R' and each R" is, independently, selected from the group consisting of hydrogen, halo, alkyl, substituted alkyl, aryl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR; wherein halo, when it appears, is other than geminal to a hydroxy, NH.sub.2, or SH; PA0 (iv) R'" is alkyl or substituted alkyl; wherein when R'" is present, wherein when R'" is present and R' is also hydrogen, R" is other than hydrogen, hydroxy, halo, thio, cyano and amino; PA0 (v) each R is, independently, selected from the group consisting of hydrogen, alkyl, substituted alkyl and aryl; PA0 (vi) n is an integer from 1 to about 5, wherein at least one carbon in (C)n has other than alkyl or hydroxy as a substituent and (C)n adj…