Purified multimerase

US6068838A · kind A · utility

Assignee

• Baxter Aktiengesellschaft · AT

Inventors

• Miha Furlan · Bern, CH
• Bernhard Laemmle · Bolligen, CH
• Hans-Peter Schwarz · Wien, AT
• Peter Turecek · Klosterneuburg, AT
• Johann Eibl · Wien, AT

Key dates

• Filing date: May 31, 1996
• Grant date: May 30, 2000
• Expiry date: May 31, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/814
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is disclosed a purified multimerase having an indirect and a direct proteolytic activity, which converts vWF having a singlet structure to vWF having a satellite structure and is active in the presence of the serine protease inhibitor DFP or the calpain protease inhibitor Z-Leu-Leu-Tyr-CHN.sub.2, as well as a method of preparing the multimerase according to the invention.