Methods of making nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers
US6068858A · kind A · utility
79Cited by
6References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 6, 1999 |
| Grant date | May 30, 2000 |
| Priority date | — |
| Expiry date | Jan 6, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/635
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention describes formulations of nanoparticulate HIV protease inhibitors comprising a cellulosic surface stabilizer. The nanoparticulate formulations have an increased rate of dissolution in vitro, an increased rate of absorption in vivo, a decreased fed/fasted ratio variability, and a decreased variability in absorption. The present invention is also directed to methods of making the novel formulations. In particular, nanoparticulate formulations of HIV type 1 (HIV-1) and type 2 (HV-2) protease inhibitors are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.