Piperazinonephenyloxazolidinone derivatives and their use as antibacterial agents

US6069145A · kind A · utility

Assignee

• Zeneca Limited · GB

Inventor

• Michael John Betts · Macclesfield, GB

Key dates

• Filing date: Jul 27, 1998
• Grant date: May 30, 2000
• Expiry date: Jul 27, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns a compound of formula (I) wherein: R.sup.1 is of the formula --NHC(.dbd.O)(1-4C)alkyl, --NHS(O).sub.n (1-4C)alkyl wherein n is 0, 1 or 2 or R.sup.1 is hydroxy; R.sup.2 and R.sup.3 are independently hydrogen or fluoro; R.sup.4 is hydrogen, methyl, ethyl or oxo; R.sup.5 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or of the formula R.sup.6 (CH.sub.2).sub.m -- wherein either m is 1-4 and R.sup.6 is, for example, trifluoromethyl, difluoromethyl, fluoromethyl, (1-4C)alkoxy, (1-4C)alkyl S(O).sub.p -- wherein p is 0, 1 or 2, (1-6C)alkanoyloxy, di-(N-(1-4C)alkyl)amino, N-((1-4C)alkyl)(1-4C)alkanoylamino, cyano, carboxy, (1-4C)alkoxycarbonyl, carbamoyl, di-(N-(1-4C)alkyl)carbamoyl, N-((1-4C)alkyl)(1-4C)alkanesulphonamido, N.sup.1 -((1-4C)alkyl)-di-(N.sup.3 -(1-4C)alkyl)ureido, or of the formula --OC(.dbd.O)NR.sup.7 (R.sup.8) or --N(R.sup.9)SO.sub.2 NR.sup.7 (R.sup.8) wherein R.sup.7 and R.sup.8 are independently hydrogen or (1-4C)alkyl and R.sup.9 is (1-4C)alkyl; or m is 2-4 and R.sup.6 is, for example, hydroxy, (1-4C)alkanoylamino, amino, (1-4C)alkylamino, (1-4C)alkanesulphonamido, ureido, di-(N.sup.3 -(1-4C)alkyl)ureido or of the formula --NHSO.sub.2 NR.su…