Process for the preparation of nizatidine
US6069256A · kind A · utility
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2References
8Claims
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Assignee
Inventor
Key dates
| Filing date | Mar 10, 1999 |
| Grant date | May 30, 2000 |
| Priority date | — |
| Expiry date | Mar 10, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a novel process for the preparation of nizatidine, N-[2-[[[2-(dimethylamino)methyl-4-thiazolyl]methyl]thio]ethyl]-N'-methyl-2 -nitro-1,1-ethenediamine, and pharmaceutically acceptable salts thereof, comprising reacting a compound of formula II ##STR1## with a compound of formula III ##STR2## or a salt thereof, in which X represents a leaving group, in the presence of methylamine in the presence of an inert diluent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.