Extracorporeal device containing immobilized chelator on silica substrate and use thereof
US6071412A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 27, 1998 |
| Grant date | Jun 6, 2000 |
| Priority date | — |
| Expiry date | Jul 27, 2018 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D2325/12
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
In an improved process for immobilizing a chelator moiety on a silica substrate, the substrate is reacted in a liquid reaction medium with an alkyltrialkoxysilane compound having a functional group that provides an attachment site for covalently binding the chelator moiety to the substrate. The improvement comprises providing a particulate silica substrate having a surface area of less than about 50 m.sup.2 /g. An improved extracorporeal device for removing metal ions from blood and other fluids includes a cartridge having an inlet and an outlet and containing a plurality of tubular fibers that extend from the inlet to the outlet. Each fiber has a lumen enclosed by an anisotropic membrane. The membrane is supported by a macroporous structure that contains a chelator moiety immobilized on a particulate silica substrate having a surface area of less than about 50 m.sup.2 /g. The anisotropic membrane forms a diffusion barrier that is permeable to metal cations contained in the fluid but is substantially impermeable to high molecular weight components. A method of removing chelatable metal cations from blood fluid uses the described extracorporeal device. The blood fluid containing the…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.