Method and composition for treating a bone tissue defect
US6071530A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 26, 1997 |
| Grant date | Jun 6, 2000 |
| Priority date | — |
| Expiry date | Jun 26, 2017 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB29K2995/006
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable, water-coagulable thermoplastic polymer and a water-miscible organic solvent. When administered to an implant site in an animal, the implant precursor will solidify in situ to a solid, microporous matrix by dissipation of the organic solvent to surrounding tissue fluids and coagulation of the polymer. The invention also includes methods of making the implant precursor, an apparatus for forming the precursor, and a kit containing the apparatus. Also provided are methods of using the implant precursor for treating a tissue defect in an animal, for example, for enhancing cell growth and tissue regeneration, wound and organ repair, nerve regeneration, soft and hard tissue regeneration, and the like, for delivery of biologically-active substances to tissue or organs, and other like therapies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.