Process for the production of crystalline aspartic acid
US6071728A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Oct 18, 1999 |
| Grant date | Jun 6, 2000 |
| Priority date | — |
| Expiry date | Oct 18, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/46
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides a process for the preparation of aspartic acid via a fermentation process for the preparation of ammonia fumarate, wherein the pH of the fermentation broth is controlled by the addition of a calcium base to produce a calcium fumarate precipitate, characterized in that ammonium fumarate is produced by separating the precipitated calcium fumarate from the fermentation broth, and reacting the same with a reagent selected from ammonia, ammonium carbonate, ammonia in combination with CO.sub.2 and mixtures therefore, to form ammonium fumarate and a co-product selected from calcium carbonate and calcium hydroxide, wherein the energy of indirect neutralization of fumaric acid by ammonia serves as the driving force for the conversion of calcium fumarate to the desired ammonium fumarate product and for the regeneration of a calcium base reagent, and wherein diammonium fumarate is enzymatically converted to ammonium aspartate and acidulated to from aspartic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.