Flavone analogues useful as anti-rejection agents

US6071883A · kind A · utility

Inventors

• Huifang Chen · Keyano, CA
• Feng Li · Auburn, US
• Luwei Liu · Keyano, CA

Key dates

• Filing date: Jul 28, 1998
• Grant date: Jun 6, 2000
• Expiry date: Jul 28, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/352
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Flavone analogues of formula ##STR1## wherein; X is O or S; PA1 R.sub.1 is C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl; PA1 R.sub.2 is H, C.sub.1 -C.sub.6 alkyl or R.sub.2 O is a sugar residue; PA1 R.sub.3 is H, C.sub.1 -C.sub.6 alkyl or R.sub.3 O is a sugar residue; PA1 R.sub.4 is H, OH, or a sugar residue; PA1 R.sub.5 is H, C.sub.1 -C.sub.6 alkyl, or R.sub.5 O is a sugar residue; PA1 m is an integer of 1 or 2; and PA1 n is an integer from 0 to 5, PA1 are useful as anti-rejection agents in organ transplants.