Sulfonamide-substituted chromans, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them

US6071953A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Hans-Jochen Lang · Hofheim, DE
• Joachim Brendel · Bad Vilbel, DE
• Uwe Gerlach · Hattersheim, DE
• Klaus Weidmann · Kronberg, DE

Key dates

• Filing date: Feb 19, 1998
• Grant date: Jun 6, 2000
• Expiry date: Feb 19, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/70
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Chromans of formula I ##STR1## with the meanings of R(A), R(B) and R(1) to R(8) stated in the specification are suitable for producing a medicament for blocking the K.sup.+ channel that is opened by cyclic adenosine monophosphate (cAMP); also for producing medicaments for inhibiting gastric acid secretion; for the treatment of ulcers of the stomach and the intestinal region, in particular the duodenum, for the treatment of reflux esophagitis, for the treatment of diarrheal disorders, for the treatment and prevention of all types of arrhythmias, including atrial, ventricular and supraventricular arrhythmias, for controlling reentry arrhythmias and for preventing sudden heart death as a result of ventricular fibrillation.