Membrane anchor/active compound conjugate, its preparation and its uses

US6074650A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Gunther Jung · Tübingen, DE
• Karl-Heinz Wiesmuller · Tübingen, DE
• Hans-Georg Rammensee · Lörrach, DE
• Hansjorg Schild · Westerburg, DE
• Karl Deres · Tübingen, DE

Key dates

• Filing date: Jun 6, 1995
• Grant date: Jun 13, 2000
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

According to certain embodiments, the invention relates to an immunoconjugate produced by conjugating at least one membrane-anchoring compound with at least one partial sequence of a protein of a virus, a bacterium, a parasite or a tumor antigen. The immunoconjugate has the advantage that it can be stored for a very long time even without cooling. According to certain embodiments, the invention relates to an immunogenic composition for the specific induction of cytotoxic T-lymphocytes which comprises a conjugate from at least one membrane anchor compound and a protein, containing at least one killer T-cell epitope, of a virus, a bacterium, a parasite or a tumor antigen, or at least one partial sequence containing at least one killer T-cell epitope of a viral, bacterial or parasite protein or of a tumor antigen.