Ursodeoxycholic acid derivatives and methods for producing them
US6075132A · kind A · utility
2Cited by
15References
9Claims
0Family size
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Key dates
| Filing date | Apr 30, 1998 |
| Grant date | Jun 13, 2000 |
| Priority date | — |
| Expiry date | Apr 30, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J17/005
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are ursodeoxycholic acid derivatives having an increased solubility in water, and methods for producing the derivatives. To produce the derivatives, ursodeoxycholic acid is protected at its carboxyl group with a benzyl group, then reacted with tetrabenzyl-acetic acid-oxyglucoside of the following formula (1), and de-benzylated; or ursodeoxycholic acid is protected at its hydroxyl group with a t-butyldimethylsilyl group, then reacted with tetrabenzyl-2-hydroxyethyloxyglucoside of the following formula (2), and de-t-butyldimethylsilylated and de-benzylated. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.