Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids

US6075143A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Gerhard Breipohl · Scheinfeld, DE
• Eugen Uhlmann · Königstein, DE
• Jochen Knolle · Kriftel, DE

Key dates

• Filing date: Mar 13, 1995
• Grant date: Jun 13, 2000
• Expiry date: Mar 13, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are described N-ethylglycine derivatives of the formula I ##STR1## in which PG is a urethane-type or trityl-type amino protective group which is labile to weak acids, X is NH, O or S, Y is CH.sub.2, NH or O, and B' are bases customary in nucleotide chemistry, the exocyclic amino or hydroxyl groups of which being protected by suitable, known protective groups, or are base substitute compounds, and their salts with tert-organic bases, as well as a process for their preparation. The N-ethylglycine derivatives of the formula I are used in the preparation of PNA and PNA/DNA hybrids.