Enhancer tolerant pressure sensitive adhesives for transdermal drug delivery
US6077527A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 28, 1997 |
| Grant date | Jun 20, 2000 |
| Priority date | — |
| Expiry date | Oct 28, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/31928
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pressure sensitive adhesive compositions for use in transdermal drug delivery systems comprising an adhesive composition which is tolerant to plasticization by cutaneous penetration enhancers contained in the transdermal drug formulation are disclosed. Specifically, the pressure sensitive adhesive composition of the present invention comprises an acrylic copolymer prepared from (i) at least 40% by weight of th total monomer composition of alkyl acrylate monomers with a Tg of -90 to 0.degree. C., (ii) 0-15% by weight of the total monomer composition of monomers with a Tg of 0 to 250.degree. C., and (iii) 10-60% by weight of the total monomer composition of substituted acrylamides or methacrylamides having the structural formula: ##STR1## wherein R.sub.1 is H or CH.sub.3, PA1 R.sub.2 is H or CH.sub.3, and PA1 R.sub.3 is (a) CH.sub.3, PA2 (b) C(CH.sub.3).sub.2 --(CH.sub.2).sub.n --CH.sub.3 where n is 0 through 17, or PA2 (c) substituents of the formula: ##STR2## where m is 0 through 10, and optionally PA2 (iv) at least 0.2% by weight of acrylic monomers containing at least one group having a reactive hydrogen, and (v) 0.01-2% by weight of a chelated metal alkoxide crosslinker to (i), …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.