Shc proteins

US6077686A · kind A · utility

Assignees

• MOUNT SINAI HOSPITAL · CA
• The University of North Carolina at Chapel Hill · US

Inventors

• Channing J. Der · Chapel Hill, US
• John Christian O'Bryan · Chapel Hill, US
• Anthony Pawson · Toronto, CA

Key dates

• Filing date: Feb 28, 1997
• Grant date: Jun 20, 2000
• Expiry date: Feb 28, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A Shc protein which is characterized as follows: (a) containing a C-terminal Src homology 2 (SH2) domain, a central proline-rich region (CH1), and an N-terminal phosphotyrosine binding (PTB) domain; (b) it is predominantly expressed in the adult brain; (c) it binds through its SH2 domain to proteins containing the consensus sequence pTyr-(hydrophobic/Glu)-(hydrophobic/Met/Tyr/Ile)-(Ile/Leu/Met/Phe/Tyr); and (d) it associates through its PTB domain with proteins containing the consensus sequence Asn-Pro-X-pTyr where X is any amino acid; nucleic acids encoding the protein; and uses of the protein. The Shc proteins mediate signaling from tyrosine kinases in the nervous system.