Keratinocyte growth factor-2

US6077692A · kind A · utility

Assignee

• HUMAN GENOME SCIENCES, INC. · US

Inventors

• Steven Ruben · Olney, US
• Pablo Jimenez · Ellicott City, US
• D. Duan · Gaithersburg, US
• Mark A. Rampy · Gaithersburg, US
• Donna Mendrick · Mount Airy, US
• Jun Zhang · Xiamen, CN
• Jian Ni · Rockville, US
• Paul A. Moore · North Potomac, US
• Timothy A. Coleman · Gaithersburg, US
• Joachim R. Gruber · Sharon, US
• Patrick J. Dillon · Carlsbad, US
• Reiner Gentz · Silver Spring, US

Key dates

• Filing date: Feb 13, 1998
• Grant date: Jun 20, 2000
• Expiry date: Feb 13, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2799/026
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.