Methods and kits for making polypeptides having a single covalently bound N-terminal water-soluble polymer

US6077939A · kind A · utility

Assignee

• Ortho-McNeil Pharmaceutical, Inc. · US

Inventors

• Ziping Wei · Montgomery, US
• Sunitha Menon-Rudolph · Willingboro, US
• Pradip Ghosh-Dastidar · Los Angeles, US

Key dates

• Filing date: Aug 4, 1997
• Grant date: Jun 20, 2000
• Expiry date: Aug 4, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/505
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides compositions consisting essentially of a polypeptide and a water-soluble polymer covalently bound thereto at the N-terminal .alpha.-carbon atom via a hydrazone or reduced hydrazone bond, or an oxime or reduced oxime bond. This invention also provides methods of making the instant compositions, pharmaceutical compositions comprising same, and kits for use in preparing same.