Diagnostic assays for MIF

US6080407A · kind A · utility

Assignee

• The Picower Institute for Medical Research · US

Inventors

• Richard J. Bucala · New York, US
• Robert A. Mitchell · Fort Mill, US
• Jurgen Bernhagen · Tübingen, DE
• Thierry Calandra · New York, US
• Anthony Cerami · Stratford, US

Key dates

• Filing date: Jun 6, 1995
• Grant date: Jun 27, 2000
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compositions and methods for inhibiting the release and/or biological activity of migration inhibitory factor (MIF). In particular, the invention relates to the uses of such compositions and methods for the treatment of various conditions involving cytokine-mediated toxicity, which include, but are not limited to shock, inflammation, graft versus host disease, and/or autoimmune diseases.