Patent · US Expired

Dinucleoside-5', 5'-pyrophosphates administered to treat HIV

US6080731A · kind A · utility

0Cited by

5References

17Claims

0Family size

Assignees

Biosearch Italia S.p.A. · IT
University of Genoa · IT

Inventors

Antonio De Flora · Genova, IT
Umberto Benatti · Genova, IT
Marco Giovine · Savona, IT

Key dates

Filing date	Jul 1, 1998
Grant date	Jun 27, 2000
Priority date	—
Expiry date	Jul 1, 2018

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

5',5'-Pyrophosphates of non-naturally occurring nucleosides selected from thymine-3'-azido-2',3'-dideoxy-D-riboside, 5-fluorouracil-2'-deoxy-D-riboside, uracil-3'-azido-2',3'-dideoxy-D-riboside, guanine-2',3'-dideoxy-D-riboside, hypoxanthing-2',3'-dideoxy-D-riboside, cytosine-2',3'-dideoxy-D-riboside, and adenine-2',3'-dideoxy-D-riboside, are described as well as their manufacture and use as therapeutical pharmaceutical compositions or as pro-drugs encapsulated into biological carriers, e.g., transformed erythrocytes, for targeting to specific cell population responsible of the development of the pathological disorders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.