2,3-dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives

US6080743A · kind A · utility

Assignee

• Novartis AG · CH

Inventors

• Pierre Acklin · Järfälla, SE
• Hans Allgeier
• Yves Auberson · Allschwil, CH
• Michel Biollaz · Riehen, CH
• Robert Moretti · Geneva, CH
• Silvio Ofner · Münchenstein, CH
• Siem Jacob Veenstra · Basel, CH

Key dates

• Filing date: Feb 27, 1998
• Grant date: Jun 27, 2000
• Expiry date: Feb 27, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/650994
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

2,3-Dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives of formula (I), ##STR1## wherein one of the radicals R.sub.1, and R.sub.2 is a group R.sub.5 and the other is a group of formula --CH(R.sub.6)--alk--R.sub.7 (Ia), --alk--CH(R.sub.6 -R.sub.7 (Ib), --alk--N(R.sub.8)--X--R.sub.7 (Ic), --alk--N.sup.+ (R.sub.8)(R.sup.9)--X--R.sub.7 A.sup.- (Id), --alk--O--X--R.sub.7 (Ie) or --alk--S--X--R.sub.7 (If), R.sub.3, R.sub.4 and R.sub.5 are each independently of the others hydrogen, lower alkyl, halogen, trifluoromethyl, cyano or nitro, R.sub.6 is unsubstituted or lower alkylated and/or lower alkanoylated amino, R.sub.7 is hydrogen; an aliphatic, cycloaliphatic or heterocycloaliphatic radical; cyano; acyl derived from carbonic acid or from a semiester or semiamide of carbonic acid, from sulfuric acid or from an aliphatic or aromatic sulfonic acid or from phosphoric acid or from a phosphonic acid ester; amino that is unsubtituted or aliphatically or araliphatically substituted and/or substituted by aliphatic, araliphatic or aromatic acyl; or an aromatic or heteroaromatic radical, R.sub.8 is hydrogen; an aliphatic or araliphatic radical; or acyl derived from an aliphatic or araliphatic carboxy…