Stimulating nerve growth with immunophilins
US6080753A · kind A · utility
9Cited by
4References
16Claims
0Family size
Assignee
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Key dates
| Filing date | Sep 15, 1997 |
| Grant date | Jun 27, 2000 |
| Priority date | — |
| Expiry date | Sep 15, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/436
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Immunophilin ligands act by binding to receptor proteins, immunophilins, which in turn can bind to and regulate the Ca.sup.2+ dependent phosphatase, calcineurin, and the Ca.sup.2+ release channel, the ryanodine receptor. Immunophilin ligands have been discovered to enhance neurite outgrowth in neuronal cell systems by increasing sensitivity to neurotrophic factors. The effects of the immunophilin ligands are detected at subnanomolar concentrations indicating therapeutic application in diseases involving neural degeneration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.