Cyclohexyl dihydrobenzofuranes

US6080782A · kind A · utility

Assignee

• Byk Gulden Lomberg Chemische Fabrik GmbH · DE

Inventors

• Wolf-Rudiger Ulrich · Konstanz, DE
• Thomas Martin · Konstanz, DE

Key dates

• Filing date: Nov 18, 1997
• Grant date: Jun 27, 2000
• Expiry date: Nov 18, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/86
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula I are selective cyclic nucleotide phosphodiesterase (PDE) inhibitors (namely of type IV). They and pharmaceutical compositions in which they are active ingredients are useful as bronchial therapeutics, for elimination of erectile dysfunction and for treatment of disorders, particularly those of inflammatory nature. The compounds are distinguished by low toxicity, good enteral absorption (high bioavailability), a great therapeutic breadth and the absence of significant side effects.