Method of treating a viral condition by inhibiting membrane fusion

US6080791A · kind A · utility

Assignees

• Seres Laboratories, Inc. · US
• The Regents of the University of California · US

Inventors

• Dale Bodian · San Francisco, US
• Judith M. White · Charlottesville, US
• Irwin D. Kuntz · Greenbrae, US
• Jay F. Stearns · Santa Rosa, US
• R. Bryan Yamasaki · Santa Rosa, US

Key dates

• Filing date: Jul 24, 1992
• Grant date: Jun 27, 2000
• Expiry date: Jul 24, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of preventing and treating a viral condition caused by an enveloped virus is described, comprising using a therapeutically effective amount of a compound selected from the group consisting of a substituted hydroquinone and the corresponding benzoquinone, wherein said hydroquinone comprises a 2-R.sup.1, 3-R.sup.2 -1,4-hydroquinone where at least one of R.sup.1 and R.sup.2 include a carbon linkage to the benzene ring of the hydroquinone. Particularly useful compounds include 5,8-dihydro-5,8-methano-1,4-naphthalenediol, 1,4-naphthoquinone, 3', 6'-dihydroxybenzo-norbornane, tert-butylhydroquinone, other diols, e.g. 1,5-naphthalenediol, and alkylated diols, e.g. 4-methoxy-1-naphthol.