Method for preparing 2-thienylethylamine derivatives
US6080875A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 2, 1999 |
| Grant date | Jun 27, 2000 |
| Priority date | — |
| Expiry date | Sep 2, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the preparation of 2-thienylethylamine derivatives of general formula: ##STR1## as well as their acid addition salts, in which R represents a halogen atom and R.sub.1 represents a C.sub.1 -C.sub.4 alkyl group, characterized in that a thienylglycidic derivative of general formula: ##STR2## in which M represents an alkali metal atom or a fraction of an alkaline-earth metal atom, is reacted with a phenylglycine ester, optionally in the form of a strong acid salt, of general formula: ##STR3## in which R and R.sub.1 have the same meaning as above, in the presence of an alkali metal borchydride of general formula: EQU X--Y IV in which X represents an alkali metal atom and Y represents a group of formula: EQU --BH.sub.3 CN or --BH.sub.(4-w) Z.sub.w in which Z represents a carboxylic acid residue and optionally in the presence of a C.sub.1 -C.sub.4 carboxylic acid, which gives the desired compound in the form of a free base which can be treated, if necessary, with an acid in order to obtain an addition salt of this compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.