Inhibitors of leaderless protein export
US6083706A · kind A · utility
7Cited by
3References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 25, 1998 |
| Grant date | Jul 4, 2000 |
| Priority date | — |
| Expiry date | Feb 25, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/68
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a compound that inhibits the binding of the leaderless protein and a transport molecule are provided. Leaderless proteins include FGF-1, FGF-2, IL-1.alpha., IL-1.beta., CNTF and HIV-tat. These methods are useful in treatment of various conditions, including tumors and diabetes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.