Polypeptide: dendrimer complexes
US6083708A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 11, 1995 |
| Grant date | Jul 4, 2000 |
| Priority date | — |
| Expiry date | Aug 11, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/545
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Compositions are disclosed, comprising dendrimers to which a first polypeptide is controllably coupled. Such polypeptide-dendrimer compositions are effective for controllably coupling a second polypeptide to the dendrimer. The first and second polypeptides have separate and distinct defined biological activities, for example, two antibodies with first and second binding specificities or an antibody and an enzymatic label. Such compositions are useful as indicators in specific binding assays, e.g., immunoassays. Methods for sequentially coupling two different polypeptides to a dendrimer to form compositions of the invention also are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.