Haemoglobin-hydroxyethyl starch conjugates as oxygen carriers
US6083909A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 6, 1999 |
| Grant date | Jul 4, 2000 |
| Priority date | — |
| Expiry date | Jan 6, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to new oxygen transfer agents which comprise haemoglobin-hydroxyethylstarch conjugates, and processes for their preparation. The invention furthermore relates to the use of the oxygen transfer agents as a blood substitute, plasma expander, perfusion agent, haemodilution agent and/or cardioplegic solution. The invention relates in particular to oxygen transfer agents which comprise a haemoglobin-hydroxyethylstarch conjugate in which the haemoglobin and the hydroxyethylstarch are linked to one another selectively via amide bonds between free amino groups of the haemoglobin and the reducing end group of the hydroxyethylstarch, which is present in oxidized form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.