Process for preparing N-demethyl-N-alkyl erythromycin derivatives

US6084079A · kind A · utility

Inventors

• Robert Keyes · Pleasant Prairie, US
• Hemant H. Patel · Edison, US
• Ramiya H. Premchandran · Gurnee, US
• Albert V. Thomas · Vernon Hills, US
• Anne H. Kemp · Palatine, US

Key dates

• Filing date: May 15, 1998
• Grant date: Jul 4, 2000
• Expiry date: May 15, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The claimed invention relates to a novel process of preparing N-demethyl-N-alkyl-4"-deoxy erythromycin A and B. The process comprises protecting the 2'-hydroxy or the 2'- and 11-hydroxy of a N-demethyl-4"-deoxy erythromycin derivative having the formula: ##STR1## where R.sub.b is H or OH, with a silyl protecting group and alkylating the N-position of the desosamine sugar.