.beta.(1-3)-glucan diagnostic assays

US6084092A · kind A · utility

Assignee

• The Collaborative Group, Ltd. · US

Inventors

• Eric Wakshull · Princeton, US
• William M. Mackin · Charlton, US
• Janet Zimmerman · Harvard, US
• Leslie W. Fisette · Hubbardston, US

Key dates

• Filing date: Dec 12, 1997
• Grant date: Jul 4, 2000
• Expiry date: Dec 12, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/975
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods of isolating .beta.(1-3)-glucan or .beta.(1-3)glucan-containing organisms in a sample, or of detecting the presence of .beta.(1-3)-glucan or .beta.(1-3)-glucan-containing organisms in a sample, utilizing binding agents for .beta.(1-3)-glucan, such as LacCer, GalCer, globotriaosylceramide and asialoganglioside-GM1, are described. Methods of diagnosing fungal infection, by detecting .beta.(1-3)-glucan or .beta.(1-3)-glucan-containing organisms, are also described. Antibodies and kits useful in the methods are also disclosed.