Co-precipitates of adenovirus with metal salts
US6086870A · kind A · utility
4Cited by
0References
27Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 21, 1998 |
| Grant date | Jul 11, 2000 |
| Priority date | — |
| Expiry date | May 21, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/10343
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides co-precipitates of metal salts and adenoviral vectors containing a transgene. The co-precipitates of the invention exhibit increased efficiency of gene transfer to a target cell relative to adenoviral vectors alone. Methods of making and using the co-precipitates are also provided. A method of delivering cystic fibrosis transmembrane conductance regulator to an individual with CF utilizing a co-precipitate of cationic molecules and adenoviral vectors containing a transgene encoding a CFTR protein is provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.