Arrays with modified oligonucleotide and polynucleotide compositions
US6087112A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 29, 1999 |
| Grant date | Jul 11, 2000 |
| Priority date | — |
| Expiry date | Sep 29, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides arrays having associated modified oligonucleotides, e.g., 2'-O-R oligonucleotides, methods of making such arrays, assays for using such arrays, and kits containing such arrays. In one embodiment, the arrays of the invention exhibit an increased binding affinity with complementary nucleic acids, and in particular with complementary RNA. In another embodiment, the associated nucleic acids of the array of the invention exhibit substantial acid resistance, allowing the arrays to be treated with low pH solutions. In another embodiment, the modified associated nucleic acids of the array of the invention exhibit substantial resistance to nuclease degradation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.