Substituted 2-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them

US6087304A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Joachim Brendel · Bad Vilbel, DE
• Heinz-Werner Kleemann · Bischofsheim, DE
• Heinrich Englert · Hofheim, DE
• Hans-Jochen Lang · Hofheim, DE
• Jan-Robert Schwark · Frankfurt am Main, DE
• Andreas Weichert · Egelsbach, DE
• Bansi Lal · Yellandu, IN

Key dates

• Filing date: May 16, 1997
• Grant date: Jul 11, 2000
• Expiry date: May 16, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/088
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted 2-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them Substituted 2-naphthoylguanidines of the formula I ##STR1## having the meanings indicated in claim 1 for R1 to R8, are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment and for the treatment of angina pectoris. They also preventively inhibit the pathophysiological processes in the formation of ischemically induced damage, in particular in the production of ischemically induced cardiac arrhythmias.