Sulfonamide-substituted compounds, process for their preparation, their use as a medicament or diagnostic, and a medicament comprising them

US6087399A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Uwe Gerlach · Hattersheim, DE
• Joachim Brendel · Bad Vilbel, DE
• Hans-Jochen Lang · Hofheim, DE
• Klaus Weidmann · Kronberg, DE

Key dates

• Filing date: Apr 27, 1999
• Grant date: Jul 11, 2000
• Expiry date: Apr 27, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## in which R(1) to R(8) and X have the meanings indicated in the specification, are useful for the production of medicaments having K.sup.+ channel-blocking action; in particular for the production of a medicament for the treatment or prophylaxis of stimulated gastric acid secretion; of ulcers of the stomach and of the intestinal region; of reflux esophagitis; of diarrhea; of all types of arrhythmias, including ventricular and supraventricular arrhythmias; and of reentry arrhythmias and for the prophylaxis of sudden heart death as a result of ventricular fibrillation.