Process of prolonging organ allograft survival
US6090413A · kind A · utility
Inventors
Key dates
| Filing date | Oct 29, 1997 |
| Grant date | Jul 18, 2000 |
| Priority date | — |
| Expiry date | Oct 29, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K35/62
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a process of prolonging organ allograft survival in an organism comprising down-regulating Th1 activity in the organism. The down-regulation of Th1 activity is accomplished either by infecting the organism with an effective Th2 up-regulating amount of a nematode or by administering to the organism an effective Th2 up-regulating amount of a soluble extract of a nematode. Exemplary and preferred nematodes for use in a process of the present invention are of the genus Nipostrongylus , Trichuris, Ascaris or Caenorhabditis. Most preferred is the nematode Nipostrongylus brasiliensis. A process of the present invention is particularly useful in prolonging kidney allograft survival.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.