Nematode-extracted serine protease inhibitors and anticoagulant proteins

US6090916A · kind A · utility

Assignee

• Corvas International, Inc. · US

Inventors

• George P. Vlasuk · Carlsbad, US
• Patrick Stanssens · Sint-Martens-Latem, BE
• Joris Hilda Lieven Messens · Dilbeek, BE
• Marc Josef Lauwereys · Haaltert, BE
• Yves Rene LaRoche · Brussels, BE
• Laurent Jespers · Tervuren, BE
• Yannick Gansemans · Ichtegem, BE
• Matthew Moyle · Redmond, US
• Peter W. Bergum · San Diego, US

Key dates

• Filing date: Nov 24, 1997
• Grant date: Jul 18, 2000
• Expiry date: Nov 24, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/829
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.