Murine monoclonal antibody binding TNF.alpha.
US6090923A · kind A · utility
4Cited by
7References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 13, 1991 |
| Grant date | Jul 18, 2000 |
| Priority date | — |
| Expiry date | Nov 13, 2011 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/525
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A cytotoxic protein expressed by human peripheral blood mononuclear cells is isolated in essentially homogenous form. This protein may be used to elicit production of polyclonal or monoclonal anti-cytotoxin antibodies. Hybridomas secreting anti-cytotoxin antibodies are identified by a solid phase bioassay. The antibodies are useful in the immunopurification of cytotoxins. The purified cytotoxic proteins are useful for the treatment of virus-infected or tumor target cells, either alone or in combination with interferon or a metabolic blocker.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.