Methods for the preparation of novel sidechain-bearing taxanes and intermediates
US6090951A · kind A · utility
5Cited by
25References
3Claims
0Family size
Inventors
Key dates
| Filing date | Aug 25, 1997 |
| Grant date | Jul 18, 2000 |
| Priority date | — |
| Expiry date | Aug 25, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.